Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
نویسندگان
چکیده
منابع مشابه
Design, Synthesis and Characterization of Small Molecules Targeting MLL1 Methyltransferase in Mixed-Lineage Leukemia
The rearrangements of the MLL located on the chromosome 11q23 are the major cause of mixed-lineage leukemia. The translocation involved in the fusion of N-terminus MLL with other fusion protein resulted in the lost of C-terminal SET domain, which is responsible for histone H3 lysine 4 methylation (H3K4). Studies showed that the wild-type MLL1 also plays a significant role in the leukaemogenesis...
متن کاملBiochemistry of the Mixed Lineage Leukemia 1 (MLL1) Protein and Targeted Therapies for Associated Leukemia
Mixed Lineage Leukemia constitutes a heterogeneous category of rare acute leukemias that are characterized by a mixed population of poorly differentiated lymphoid and myeloid progenitor cells. The mixed lineage leukemia (MLL1) gene, also known as HRX or ALL-1, is a frequent site of genetic rearrangements in infant acute leukemias and therapy-related malignancies (Daser and Rabbitts, 2005) and s...
متن کاملTrithorax group genes in hematopoiesis
Hematopoietic stem and progenitor cells maintain blood homeostasis by giving rise to all mature blood cells and lymphocytes. A recent study identified the trithorax group gene ash1l as a critical regulator of quiescence and self-renewal potential in adult hematopoietic stem cells [1]. Ash1l encodes a large protein with histone methyltransferase activity that cooperates with the leukemia-associa...
متن کاملNeuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.
Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular phenotypes after neuron-specific deletion of H3K4 methyl-regulators remain largely unexplored. We report that neuronal ablation of the H3K4-specific methyltransferase, Kmt2a/Mixed-lineage leukemia 1 (Mll1), in mouse postnatal forebrain a...
متن کاملInhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16
Leukemia stem cells (LSC) are resistant to conventional chemotherapy and persistent LSC after chemotherapy are supposed to be a major cause of relapse. However, information on genetic or epigenetic regulation of stem cell properties is still limited and LSC-targeted drugs have scarcely been identified. Epigenetic regulators are associated with many cellular processes including maintenance of st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2014
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2013.12.001